Найден ген, провоцирующий повышенный аппетит

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16/07/2013 comment

Scientists from University College London came to the conclusion that every sixth person in connection with a mutation in the gene FTO, shortly after a meal is experiencing a strong feeling of hunger.

All these people have overestimated the level of hunger hormone (ghrelin) in the blood. Researchers conducted a study in which volunteers were shown images of mouth-watering dishes. All of whose the FTO gene is mutated, revealed a high level of activity in the region of the brain that is associated with appetite and reward. The study will answer the question, why these people have an increased appetite and dependent on-calorie foods.

In the experiment took part 359 men with two copies of the genetic variation, or of the FTO gene. Mainly ghrelin levels are reduced after a meal, in connection with which suppresses the feeling of hunger. But, as shown samples of blood of 20 participants in the study of men with a high risk of gene mutation hormone after the end of the meal, not began to decline, remaining at the same high level.

Risk group underwent an MRI procedure, after which it turned out that there was a high activity in the hypothalamus (in charge of the regulation of appetite) and in the area of the brain that is associated with the award.

“We’ve known that obesity and changes in the gene FTP somehow connected, but the reason remained a mystery to us. After research it became clear that people with two copies of the genetic variation FTO gene is programmed on the biological level, the consumption of larger amounts of food. Also these people increased levels of ghrelin, which they feel a sense of hunger, because their brain special responds to the hormone and the image of delicious dishes,” says Rachel Баттерхэм, the author of the work.

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